A Protein Interaction Extraction System

We consider the problem of extracting, manipulating, and managing pathways, especially protein-protein interaction pathways. We discuss here the Protein Interaction Extraction System (PIES). The PIES is con-tructed on top of three main technologies: Kleisli, BioNLP, and Graphviz. Kleisli is a broad-scale data integration system that we use for downloading Medline abstracts and for general manipulation and management of pathway/interaction databases. BioNLP is a natural language-based information extraction module that we use for analysing Medline abstracts and to extract precise protein-protein and other interaction information. Graphviz is a graphically layout package developed for directed graphs that we use for visualization of the extracted pathways. The PIES can be augmented with means for extracting protein interaction information from sequence databases, for example, by using Kleisli's power to integrate sequence comparison tools to detect gene fusion events in sequence databases.